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Assessing the determinants of durable protective immunity in SARS-CoV-2 infected human subjects
While natural immunity from a primary infection stands as our only barrier against reinfection, to date no study has determined if a primary infection generates long-lived durable anti-SARS-CoV-2 adaptive immunity. To this end, our studies will examine...
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Development of a primary healthcare system
Develop primary care system including community health workers in a mixed Colombia-Venezuelan barrio of 1700 families in a city on the Colombia-Venezuela border. In colaboration with the NGO "MedGlobal" (Chicago, Ill) ...
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Community care model improves uptake of TB preventive therapy, KZN study finds
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Multi-center, Randomized, Double-blind, Placebo-controlled Phase 3 Efficacy Study of a Heterologous Vaccine Regimen of Ad26.Mos4.HIV and Adjuvanted Clade C gp140 and Mosaic gp140 to Prevent HIV-1 Infection Among Cis-gender Men and transgender Individuals
To evaluate the vaccine efficacy (VE) of a heterologous vaccine regimen utilizing Ad26.Mos4.HIV and aluminum phosphateadjuvanted Clade C gp140 and Mosaic gp140 for the prevention of HIV-1 infection in HIV-1 seronegative cis-gender men and transgender...
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Mortality and Causes of Death Measurement
IHME is developing and advancing methods for quantifying the levels of mortality by age and sex for every country in the world, by improving upon past methods and developing new tools for analyzing missing, incomplete, and biased data. Researchers are...
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Subclinical cardiac dysfunction after delivery
This was a 2-year training and research grant supported by NIH Fogarty International Center It is a cross-sectional study to estimate the burden and characteristics of cardiac dysfunction in Kenya, following HDP. Women with HDP were recruited after...
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Neutralizing and non-neutralizing antibody effector functions in HIV infected children
This project aims to compare the frequency of broadly neutralizing B cell receptor progenitors between adults and young children. ...
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Seattle’s nights are hotter than ever. Climate change means more to come
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The Atlantic: How Back Pain Took Over the World
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Multivalent Flavivirus Vaccine Development Using a Flexible Replicating RNA Platform
This project seeks to develop a novel, bivalent, thermostable self-amplifying RNA vaccine against two flaviviruses (Yellow Fever and Zika) from preclinical studies to GMP manufacturing and a Phase 1 clinical. ...