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Identification of drug-targetable IFN-stimulated genes mediating immune activation during ART-treated HIV-1 infection

This project seeks to understand how expression interferon stimulated genes (ISGs) changes following HIV-1 infection and how ISG expression correlates with immunophenotypes and the HIV-1 reservoir. Using that information we will use novel bioinformatics approaches to identify existing drugs that could be repurposed for reducing HIV-1-associated immune activation.

Active Dates 
06/05/2018 to 05/31/2023
Faculty Involved 
Health Topics