- Adjunct Professor, Global Health
- Professor, Immunology
- Adjunct Professor, Microbiology
UW Department of Immunology
Office E383, Box 358059
750 Republican Street
Box UW Mailbox: 357650
Seattle, WA 98109
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Dr. Michael Gale, Jr. received his training at the University of Washington School of Public Health and Community Medicine. He served on the faculty of the University of Texas Southwestern Medical Center until joining the University of Washington in 2007.
Research in the Gale laboratory focuses on understanding the virus-host interactions that control innate immunity and viral disease, and on defining the molecular processes by which innate immunity controls the outcome of infection and immunity in response to emerging viral pathogens of global health importance. The lab uses molecular, biochemical, and functional genomics approaches to study SARS-CoV-2, HIV, Zika virus, West Nile virus, Hanta virus, influenza A virus, and other emerging and re-emerging viruses. The group is also involved in developing and testing small molecule therapeutics for clinical application to control innate immunity and virus infection and to enhance vaccine efficacy.
More information on Dr. Gale and the Gale Lab can be found here.
- PhD (University of Washington)
- BS (University of Washington)
- Biodefense Infectious Diseases
- Host-Pathogen Interactions
- Infectious Diseases
- Infectious Diseases (other than STDs)
- Innate Immunity
- Molecular Immunology
- Respiratory Disease
Virus-host interactions that control innate defenses and immunity to infection; genetic and functional analysis of the innate immune antiviral response; interferon biology; immune control of the replication and pathogenesis of hepatitis C virus, West Nile virus, and human immunodeficiency virus; flaviviruses.
- Antivirals for Biodefense
- Center for Emerging and Re-emerging Infectious Diseases
- Center for Innate Immunity and Immune Disease (CIIID)
- Center for the Study of Immune Mechanisms of Virus Control
- CFAR: Immunology Core
- Development of a Novel Innate Immune Adjuvant System for Emerging RNA Virus Vaccines
- Enterovirus in China
- Immune Mechanisms of Protection Against Mycobacterium Tuberculosis Center (Cascade IMPAc-TB)
- Innate Immune Antivirals for Biodefense
- Innate immune control of West Nile virus
- Innate immune regulation of Zika virus infection
- JAK-STAT Control of Zika Virus-Induced Fetal Injury
- Leadership Group of Infectious Diseases Clinical Research Consortium (IDCRC).
- Mechanisms of hepatic innate immune activation by HCV and HBV
- Systems Immunogenetics of Biodefense Pathogens in the Collaborative Cross
- Targeting IRFs for immune adjuvant enhancement of vaccine immunogenicity
- The Host Response to Hepatitis C Virus
- Transcriptomic analysis of the protective host response to CMV-TB and CMV-SIV vaccination
- University of Washington Arboviral Research Network (UWARN)
- Viral Hepatitis in Japan
Esser-Nobis K, Hatfield LD, Gale M Jr. Spatiotemporal dynamics of innate immune signaling via RIG-I-like receptors. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15778-15788. doi: 10.1073/pnas.1921861117. Epub 2020 Jun 22. PMID: 32571931; PMCID: PMC7354926.
Kell AM, Hemann EA, Turnbull JB, Gale M Jr. RIG-I-like receptor activation drives type I IFN and antiviral signaling to limit Hantaan orthohantavirus replication. PLoS Pathog. 2020 Apr 24;16(4):e1008483. doi: 10.1371/journal.ppat.1008483. [Epub ahead of print] PubMed PMID: 32330200.
Barrenas F, Raehtz K, Xu C, Law L, Green RR, Silvestri G, Bosinger SE, Nishida A, Li Q, Lu W, Zhang J, Thomas MJ, Chang J, Smith E, Weiss JM, Dawoud RA, Richter GH, Trichel A, Ma D, Peng X, Komorowski J, Apetrei C, Pandrea I, Gale M Jr. Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control. Nat Commun. 2019 Nov 8;10(1):5101. doi: 10.1038/s41467-019-12987-9. PubMed PMID: 31704931; PubMed Central PMCID: PMC6841668.
Negash, A.A., Ramos, H.J., Crochet, N., Lau, D.T., Doehle, B., Papic, N., Delker, D.A., Bertoletti, A., Hagedorn, C.H., Gale, M. Jr. (2013) IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease. PLoS Pathog. 9:e1003330. PMID: 23633957 PMCID: PMC3635973