• Adjunct Professor, Global Health
  • Professor, Immunology
  • Adjunct Professor, Microbiology
Michael Gale

UW Department of Immunology
Office E383, Box 358059
750 Republican Street
Box UW Mailbox: 357650
Seattle, WA 98109
United States

Phone Number: 
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Dr. Michael Gale, Jr. received his training at the University of Washington School of Public Health and Community Medicine. He served on the faculty of the University of Texas Southwestern Medical Center until joining the University of Washington in 2007.

Research in the Gale laboratory focuses on understanding the virus-host interactions that control innate immunity and viral disease, and on defining the molecular processes by which innate immunity controls the outcome of infection and immunity in response to emerging viral pathogens of global health importance. The lab uses molecular, biochemical, and functional genomics approaches to study SARS-CoV-2, HIV, Zika virus, West Nile virus, Hanta virus, influenza A virus, and other emerging and re-emerging viruses. The group is also involved in developing and testing small molecule therapeutics for clinical application to control innate immunity and virus infection and to enhance vaccine efficacy.

More information on Dr. Gale and the Gale Lab can be found here

  • PhD (University of Washington)
  • BS (University of Washington)
Country Affiliations 
  • German
Health Topics 
  • Biodefense Infectious Diseases
  • Cancer
  • Genomics
  • Host-Pathogen Interactions
  • Infectious Diseases
  • Infectious Diseases (other than STDs)
  • Influenza
  • Informatics
  • Innate Immunity
  • Molecular Immunology
  • Respiratory Disease
  • TB
  • Viruses
Pathobiology research areas 

Virus-host interactions that control innate defenses and immunity to infection; genetic and functional analysis of the innate immune antiviral response; interferon biology; immune control of the replication and pathogenesis of hepatitis C virus, West Nile virus, and human immunodeficiency virus; flaviviruses. 


Esser-Nobis K, Hatfield LD, Gale M Jr. Spatiotemporal dynamics of innate immune signaling via RIG-I-like receptors. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15778-15788. doi: 10.1073/pnas.1921861117. Epub 2020 Jun 22. PMID: 32571931; PMCID: PMC7354926.

Kell AM, Hemann EA, Turnbull JB, Gale M Jr. RIG-I-like receptor activation drives type I IFN and antiviral signaling to limit Hantaan orthohantavirus replication. PLoS Pathog. 2020 Apr 24;16(4):e1008483. doi: 10.1371/journal.ppat.1008483. [Epub ahead of print] PubMed PMID: 32330200.

Barrenas F, Raehtz K, Xu C, Law L, Green RR, Silvestri G, Bosinger SE, Nishida A, Li Q, Lu W, Zhang J, Thomas MJ, Chang J, Smith E, Weiss JM, Dawoud RA, Richter GH, Trichel A, Ma D, Peng X, Komorowski J, Apetrei C, Pandrea I, Gale M Jr. Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control. Nat Commun. 2019 Nov 8;10(1):5101. doi: 10.1038/s41467-019-12987-9. PubMed PMID: 31704931; PubMed Central PMCID: PMC6841668.

Negash, A.A., Ramos, H.J., Crochet, N., Lau, D.T., Doehle, B., Papic, N., Delker, D.A., Bertoletti, A., Hagedorn, C.H., Gale, M. Jr. (2013) IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease. PLoS Pathog. 9:e1003330. PMID: 23633957 PMCID: PMC3635973