- Adjunct Associate Professor, Global Health
- Associate Professor, Medicine - Allergy and Infectious Dis.
- Adjunct Associate Professor, Microbiology
750 Republican St
UW Medicine Box 358061
Seattle, WA 98109
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The Hybiske laboratory is broadly interested in the interactions between intracellular pathogens and host cells. The lab is particularly interested in the pathways used by intracellular organisms to exit host cells. This research encompasses the underlying molecular mechanisms of these processes and the illumination of how these strategies facilitate unique interactions with the host immune system, most notably for immune evasion.
A major research focus in the lab is to decipher the mechanisms by which the intracellular pathogens Chlamydia and malaria manipulate cellular function in order to exit host cells and cause infectious disease. Collectively, diseases caused by Chlamydia and malaria are the among the most devastating and widespread to plague mankind; effective intervention strategies are sorely lacking. And remarkably, these two disparate pathogens have coevolved similar mechanisms for escaping their respective host cells and disseminating within human hosts. Our ultimate goal is to leverage a thorough understanding of these pathogenic mechanisms as a new, unexplored therapeutic platform.
- PhD (University of California (Berkeley))
- BS (University of California (Berkeley))
- Drug and Vaccine Development
- Host-pathogen Interactions
- Infectious Diseases
- STDs (other than HIV)
Sherrid A, Hybiske K. Chlamydia trachomatis cellular exit alters interactions with host dendritic cells. Infect Immun. 2017 85(5):e00046-17. PMID 28223346.
Zuck M, Ellis TC, Venida A, Hybiske K. Extrusions promote engulfment and Chlamydia survival within macrophages. Cell Microbiol. 2017 19(4):doi: 10.1111/cmi.12683. PMID 27739160.
Zuck M, Sherrid A, Suchland RJ, Ellis TC, Hybiske K. Conservation of extrusion as an exit mechanism for Chlamydia. Pathog Dis. 2016 74(7):pii:ftw093. PMID 27620201.
Hybiske K. Expanding the molecular toolkit for Chlamydia. Cell Host Microbe. 2015 18(1):11-3. PMID 26159716.
Hybiske K, Stephens RS. Mechanisms of host cell exit by the intracellular bacterium Chlamydia. Proc Natl Acad Sci USA, 2007 104(27):11430-11435. PMID: 17592133.