• Professor, Department of Laboratory Medicine
  • Head, Virology Division, Department of Laboratory Medicine
  • Director, UW Molecular Virology Laboratory
  • Director, UW Virology Laboratory
  • Member, Fred Hutchinson Cancer Research Center
Keith Jerome

Fred Hutchinson Cancer Research Center
1100 Fairview N
Seattle WA 98109

Campus Box: 358080

Phone Number: 
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My research interests focus on chronic and latent viral infections, and potential approaches to their eradication. Much of our work involves the use of DNA editing enzymes, including homing endonucleases, zinc finger nucleases, and TAL effector nucleases, to induce deletion of essential viral genes or cellular receptors for virus. We have active projects in HIV, hepatitis B virus, herpes simplex virus, and human papillomavirus. Our long-term goal is to develop curative therapies for each of these infections. Clinically, I serve as Director of the University of Washington molecular virology laboratory, and consult regarding all aspects of virology testing. Specific areas of interest include real time PCR, automation of nucleic acid extraction, and diagnosis of disease caused by herpes viruses, enterovirus, JC and BK viruses, parvovirus B19, and hepatitis viruses.

Health Topics 
  • Infectious Diseases
  • Pathobiology
Pathobiology research areas 
DGH Centers, Programs and Initiatives and Affiliated Organizations 

Stone, D, Kiem H-P, Jerome KR. 2013. Targeted gene disruption to cure HIV.. Current opinion in HIV and AIDS. 8(3):217-23.

Munro, SB, Kuypers J, Jerome KR. 2013. Comparison of a Multiplex Real-Time PCR Assay with a Multiplex Luminex Assay for Influenza Virus Detection.. Journal of clinical microbiology.

Xu, M, Qin X, Astion ML, Rutledge JC, Simpson J, Jerome KR, Englund JA, Zerr DM, Migita RT, Rich S et al.. 2013. Implementation of filmarray respiratory viral panel in a core laboratory improves testing turnaround time and patient care.. American journal of clinical pathology. 139(1):118-23.

Wagner, TA, Lin C-H, Tobin NH, Côté HCF, Sloan DD, Jerome KR, Frenkel LM. 2013. Quantification of mitochondrial toxicity in HIV-infected individuals by quantitative PCR compared to flow cytometry..Cytometry. Part B, Clinical cytometry. 84B(1):55-58.

Sedlak, RH, Jerome KR. 2013. Viral diagnostics in the era of digital polymerase chain reaction..Diagnostic microbiology and infectious disease. 75(1):1-4.

Day, SL, Odem-Davis K, Mandaliya KN, Jerome KR, Cook L, Masese LN, Scott J, Kim HN, Graham SM,McClelland SR. 2013. Prevalence, clinical and virologic outcomes of hepatitis B virus co-infection in HIV-1 positive Kenyan women on antiretroviral therapy.. PloS one. 8(3):e59346.

Schiffer, JT, Swan D, Al Sallaq R, Magaret A, Johnston C, Mark KE, Selke S, Ocbamichael N, Kuntz S, Zhu Jet al.. 2013. Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract.. eLife. 2:e00288.