• Affiliate Professor, Global Health

Seattle, WA
United States

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The focus of James Berkley's research group is serious infection and survival in highly vulnerable groups of infants and children. Dr. Berkley is the Director of the CHAIN Network studying acute illness and recovery in relation to nutritional status at sites in Africa (Kenya, Uganda, Malawi, Burkina Faso) and South Asia (Pakistan, Bangladesh). CHAIN aims to better understand infectious, immune, metabolic, nutritional and social factors that could be modified to reduce mortality in hospital and after discharge amongst the most vulnerable children.

Current trials include examining alternative first-line antimicrobials in severely malnourished children to prevent mortality (FLACSAM), including determining pharmacokinetics, and the presence and acquisition of ESBL and other forms of antimicrobial resistance influencing antimicrobial choices. Dr. Berkley's research group is determining antimicrobial resistance to potential antimicrobial combinations for neonatal sepsis and conducting a PK study to assess the potential for using IV and oral fosfomycin NeoFosfo).

The Kilifi Perinatal and Maternal Health (KIPMAT) study is examining background, maternal and delivery-associated risk factors for adverse birth outcomes and neonatal infection.

Dr. Berkley is an expert advisor to WHO on antimicrobials for treating common childhood infection, and on management of severe malnutrition.

  • MD (University of Newcastle-on-tyne (UK))
  • Master's (University of Liverpool)
  • MBBS (University of Newcastle-on-tyne (UK))
Health Topics 
  • Burden of Disease
  • Child and Adolescent Health (incl. Pediatrics)
  • Child Mortality
  • Diarrheal Diseases
  • Epidemiology
  • Health Interventions
  • Infectious Diseases (other than STDs)
  • Maternal Child Health (incl. Reproductive Health)
  • Nutrition
  • Research
DGH Centers, Programs and Initiatives and Affiliated Organizations 

Mramba L, Ngari M, Mwangome M, Muchai L, Bauni E, Walker AS, Gibb DM, Fegan G, Berkley JA. A growth reference for mid upper arm circumference for age among school age children and adolescents, and validation for mortality: growth curve construction and longitudinal cohort study. BMJ. 2017;358:j3423. PMID pending

Mwangome M, Ngari M, Fegan G, Mturi N, Shebe M, Bauni E, Berkley JA. Diagnostic criteria for severe acute malnutrition among infants aged under 6 mo. Am J Clin Nutr. 2017 Jun;105(6):1415-1423. PMID: 28424189

Ngari MM, Fegan G, Mwangome MK, Ngama MJ, Mturi N, Scott JAG, Bauni E, Nokes DJ, Berkley JA. Mortality after Inpatient Treatment for Severe Pneumonia in Children: a Cohort Study. Paediatr Perinat Epidemiol. 2017 May;31(3):233-242. PMID: 28317139

Seale AC, Koech AC, Sheppard AE, Barsosio HC, Langat J, Anyango E, Mwakio S, Mwarumba S, Morpeth SC, Anampiu K, Vaughan A, Giess A, Mogeni P, Walusuna L, Mwangudzah H, Mwanzui D, Salim M, Kemp B, Jones C, Mturi N, Tsofa B, Mumbo E, Mulewa D, Bandika V, Soita M, Owiti M, Onzere N, Walker AS, Schrag SJ, Kennedy SH, Fegan G, Crook DW, Berkley JA.
Maternal colonization with Streptococcus agalactiae and associated stillbirth and neonatal disease in coastal Kenya.
Nat Microbiol. 2016 May 23;1(7):16067. PMID: 27572968

Berkley JA, Ngari M, Thitiri J, Mwalekwa L, Timbwa M, Hamid F, Ali R, Shangala J, Mturi N, Jones KD, Alphan H, Mutai B, Bandika V, Hemed T, Awuondo K, Morpeth S, Kariuki S, Fegan G. Daily co-trimoxazole prophylaxis to prevent mortality in children with complicated severe acute malnutrition: a multicentre, double-blind, randomised placebo-controlled trial. Lancet Glob Health. 2016 Jul;4(7):e464-73. PMID: 27265353