- Professor, Global Health
- Professor, Epidemiology
- Professor, Medicine - Allergy and Infectious Dis.
- Professor, Pediatrics
Global Center for Integrated Health of Women, Adolescents and Children (Global WACh)
325 9th Avenue, Box 359909
Seattle, WA 98104
United States
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Dr. John-Stewart's major research interest focuses on advancing HIV prevention and treatment. She directs studies aimed at defining mechanisms of HIV transmission from mothers to infants, HIV prevention in women, and pediatric/adolescent HIV. Particular research interests include prevention of mother-to-child HIV transmission (PMTCT) clinical trials, implementation science and evaluation studies, studies of PrEP in MCH and FP clinics, pediatric and adolescent HIV studies, HIV treatment programs and evaluation. Her group also focuses on maternal-child epidemiologic studies in the context of infectious diseases including studies of the mechanism of breastfeeding protective effects, child growth and neurocognitive outcomes, preterm birth, viral infections with EBV, CMV, STIs, and TB. Studies of TB, growth, birth outcomes, and STIs include both women and cihildren living with HIV and those without.
- BS (University of Michigan)
- MD (University of Michigan)
- MPH (University of Washington)
- PhD (University of Washington)
- Child and Adolescent Health (incl. Pediatrics)
- Child Mortality
- Epidemiology
- HIV Transmission
- Infectious Diseases
- Infectious Diseases (other than STDs)
- Maternal Child Health (incl. Reproductive Health)
- Mental Health
- Nutrition
- STDs (other than HIV)
- TB
molecular epidemiology, clinical trials, HIV research, MCH, HIV co-infections (TB, CMV, EBV)
- Azithromycin to prevent post-discharge mortality and morbidity in Kenyan children
- Cytomegalovirus (CMV) viremia and mortality in HIV-infected hospitalized children
- Data Informed Stepped Care (DISC) to Improve Adolescent HIV Outcomes
- Delivering PrEP in pregnancy (PrIMA)
- Evaluation of Option B+ in Kenya
- Impact of periconceptual vaginal microbiota on women's risk of preterm birth
- Infant immune mechanisms of HIV reservoir size and decay
- Maternal-infant virome transmission: the role of HIV and antiretroviral therapy
- PrEP adherence among Adolescent Girls and Young Women (AGYW): a multidimensional evaluation
- Preventing Mycobacterium tuberculosis infection in HIV-exposed infants
- Scaling up the systems analysis and improvement approach for prevention of mother-to-child HIV transmission in Mozambique (SAIA-SCALE)
- Simulated patient encounters to promote early detection and engagement in HIV care for adolescents
- Systems Analysis and Improvement Approach to Optimize the Pediatric HIV Diagnosis and Care Cascade (SAIA-PEDS)
- The effect of HIV exposure and infection on immunity to TB in children
- Transitioning from Pediatric to Adult HIV Care in Kenya
Njuguna I, Cranmer L, Otieno V, Mugo C, Okinyi H, Benki-Nugent S, Richardson B, Stern J, Maleche-Obimbo L, Wamalwa D, John-Stewart G. Urgent versus post-stabilization antiretroviral treatment in hospitalized children: a randomised trial. Lancet HIV 2018; 5(1):e12-e22.doi:10.106/S2352-3018 (17) 30167-4. PMCID: PMC5777310
Pintye J, Drake A, Kinuthia J, Unger J, Matemo D, Heffron R, Barnabas R, Kohler P, McClelland RS, John-Stewart G. A risk assessment tool for identifying pregnant and postpartum women who may benefit from pre-exposure prophylaxis (PrEP). Clin Infect Dis 2016; 64 (6):751-8. PMC6075205.
Walson JL, Singa BO, Sangaré L, Naulikha J, Piper B, Richardson BA, Otieno PA, Mbogo LW, Berkley J, John-Stewart G. Empiric deworming to delay HIV disease progression in adults with HIV who are ineligible for initiation of antiretroviral treatment (the HEAT study): a multi-site, randomised trial.. Lancet Infect Dis 2012 Dec;12(12):925-32. PMID: 22971323.
Jonnalagadda S, Lohman Payne B, Brown E, Wamalwa D, Maleche Obimbo E, Majiwa M, Farquhar C, Otieno P, Mbori-Ngacha D, John-Stewart G. Latent tuberculosis detection by interferon gamma release assay during pregnancy predicts active tuberculosis and mortality in human immunodeficiency virus type1-infected women and their children. J Infect Dis. 2010;202(12):1826-35. PMCID: 3058232.
Nduati R, John G, Mbori-Ngacha D, Richardson B, Overbaugh J, Mwatha A, Ndinya-Achola J, Bwayo J, Onyango FE, Hughes J, Kreiss J. Effect of breastfeeding and formula feeding on transmission of HIV-1: a randomized clinical trial. JAMA. 2000 Mar 1;283(9):1167-74. PMID: 10703779.