- Affiliate Professor, Global Health
Center for Infectious Disease Research
307 Westlake Ave N, Suite 500
Seattle, WA 98109
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Don Sodora is a Professor at the Center for Infectious Disease Research. The Sodora Laboratory investigates the ability of HIV to be transmitted from mothers to their children, as well as to understand how an HIV infection leads to immune dysfunction and AIDS. Many of their studies utilize the SIV virus, highly analogous to HIV, which infects numerous monkey species. Regarding HIV transmission, our studies focus on developing an HIV vaccine that can be delivered to a mucosal site (in collaboration with Noah Sather’s laboratory). To assess immune dysfunction our laboratory focuses on immunologic changes in the liver that occur during HIV/SIV infection. Don received his PhD in Microbiology from the University of Pennsylvania. He performed postdoctoral research at Stanford University and the Aaron Diamond AIDS Research Center in New York. Dr. Sodora has collaborators in Atlanta, Philadelphia, Oregon, Northern Ireland and Cape Town South Africa. He is dedicated to the training of undergraduate and graduate students, including serving on the Graduate Student Advisory Committee for the Pathobiology Graduate Program at the University of Washington.
- PhD (University of Pennsylvania)
- BS (Rutgers University)
- HIV Transmission
HIV transmittal and AIDS, developing new therapies and vaccines
Gasper MA, Hesseling AC, Mohar I, Myer L, Azenkot T, Passmore JS, Hanekom W, Cotton MF, Crispe IN, Sodora DL†, and Jaspan, HB†. (2017) BCG vaccination induces HIV target cell activation in HIV-exposed infants in a randomized trial. Journal of Clinical Investigation Insight, 2(7):e91963. † Equal Contribution. PMID: 28405623
Palesch D, Bosinger SE, Tharp GK, Vanderford TH, Paiardini M, Chahroudi A, Johnson ZP, Kirchhoff F, Hahn BH, Norgren RB Jr., Patel NB, Sodora DL, Dawoud RA, Harris RA, Liu Y, Raveendran M, Han Y, English A, Thomas GWC, Hahn MW, Pipes L, Mason CE, Muzny DM, Gibbs RA, Sauter D, Worley K, Rogers J, Silvestri G. (2017) Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host. Nature. Jan 3;553(7686):77-81 PMID: 29300007
Wood LF, Wood M, Fisher B, Jaspan HB, Sodora DL. (2017) T Cell Activation in South African HIV-Exposed Infants Correlates with Ochratoxin-A Exposure. Frontiers in Immunology, Section: Nutritional Immunology. Dec 22;8:1857. PMID:29312338
Fisher BS, Green RR, Brown RR, Wood MP, Hensley-McBain T, Fisher C, Chang J, Miller AD, Bosche WJ, Lifson JD, Mavigner M, Miller CJ, Gale M Jr., Silvestri G, Chahroudi A, Klatt NR, Sodora DL. (2018). Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART. PLoS Pathog. 2018 Feb 21;14(2):e1006871. PMID 29466439.
Wood LF, Brown B, Lennard K, Karaoz U, Havyarimana E, Passmore JS, Hesseling AC, Edelfson P, Kuhn L, Mulder N, Brodie E, Sodora DL, and Jaspan HB. Exclusive breast-feeding of South African infants reduces mucosal inflammation and peripheral T cell activation in association with microbiome diversity. 2018. Clinical Infectious Diseases. PMID 29659737