- Adjunct Professor, Global Health
- Professor, Medicine - Allergy and Infectious Dis.
- Professor, Laboratory Medicine and Pathology
The Koelle Lab
750 Republican St., Room E651
Seattle, WA 98109
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Our lab works on the T cell immune response to a variety of human pathogens. Currently funded projects include Treponema pallidum (syphilis), herpes simplex virus types 1 and 2, varicella zoster virus (the cause of chicken pox and shingles), SARS-CoV-2, and Merkel cell polyoma virus (MCPyV, the cause of a viral skin cancer). We are fortunate to work with translational scientists including animal models and analysis of human specimens from vaccine clinical trials. David also does clinical work in Infectious Diseases at Harborview Medical Center,a component of UW Medicine.
- MD (University of Washington)
- BS (University of Washington)
- Host-Pathogen Interactions
- Infectious Diseases (other than STDs)
- Molecular Immunology
- STDs (other than HIV)
Human and mouse immune responses to medically significant viral and protozoal pathogens, with an emphasis on T-cell responses.
- Immunodominant Viral Memory CD4 Epitopes of Biosecurity & Geriatric Medicine Concern
- Immunology of Merkel cell carcinoma
- Large Scale T cell epitope discovery
- Mechanisms of Severe T-cell Mediated Drug Hypersensitivity in Man
- T cell immune response to syphilis
- Tissue resident memory response to VZV infection
Jing L, Ott M, Church CD, Kulikauskas RM, Ibrani D, Iyer JG, Afanasiev OK, Colunga AG, Cook MM, Xie H, Greninger AL, Paulson KG, Chapuis AG, Bhatia S, Nghiem P, Koelle DM. 2020. High prevalence and diverse HLA restriction of intratumoral oncoprotein-specific CD8 T cells in polyoma virus-driven Merkel cell carcinoma. Cancer Immunology Research 8: 648-659. PMID 32179557. PMCID 7197523.
Koelle DM, Norberg P, Fitzgibbon MP, Russell RM, Greninger AL, Huang ML, Stensland L, Jing L, Magaret AS, Diem K, Selke S, Xie H, Celum C, Lingappa JR, Jerome KR, Wald A, Johnston C. 2017. Worldwide circulation of HSV-2 x HSV-1 recombinant strains. Scientific Reports 7: 44084. PMID 28287412. PMC ID PMC 5372922. [original work]
van Velzen M, Jing L, Osterhaus ADME, Sette A, Koelle DM*, Verjans GMGM* (*Co-senior author). 2013. Local CD4 and CD8 T-cell reactivity to HSV-1 antigens documents broad viral protein expression and immune competence in human ganglia. PLoS Pathogens 9:e1003547. PMID 23966859. PMCID: PMC3744444.
Enrichment of herpes simplex virus type 2 (HSV-2) reactive mucosal T cells in the human female genital tract. Posavad CM, Zhao L, Dong L, Jin L, Stevens CE, Magaret AS, Johnston C, Wald A, Zhu J, Corey L, Koelle DM. Mucosal Immunol. 2017 Sep;10(5):1259-1269. PMID: 28051084
Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA. Paulson KG, Voillet V, McAfee MS, Hunter DS, Wagener FD, Perdicchio M, Valente WJ, Koelle SJ, Church CD, Vandeven N, Thomas H, Colunga AG, Iyer JG, Yee C, Kulikauskas R, Koelle DM, Pierce RH, Bielas JH, Greenberg PD, Bhatia S, Gottardo R, Nghiem P, Chapuis AG. Nat Commun. 2018 Sep 24;9(1):3868. PMID: 30250229