- Affiliate Associate Professor, Global Health
Center for Infectious Disease Research
307 Westlake Avenue N, Suite 500
Seattle, WA 98109
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Mycobacterium tuberculosis (Mtb) remains the most deadly bacterial pathogen, and rampant drug resistance is requiring renewed efforts to find new and better therapies. The Grundner lab seeks to map the signaling pathways that underlie Mtb’s adaptability and pathogenesis. These studies provide fundamental insight into Mtb biology and identify new targets for therapeutic interference. A major bottleneck in Mtb research on every level is the large number of genes with unknown function in the Mtb genome. We use chemical proteomics approaches towards high-throughput identification of functions for these unknown proteins. These new tools allow probing of even the most divergent enzyme space.
- PhD (University of Heidelberg (Germany))
- MS (Humboldt University (Germany))
- BS (University of Bonn (Germany))
- Infectious Diseases
Ortega C, Frando A, Webb-Robertson BJ, Anderson LN, Fleck N, Flannery EL, Fishbaugher M, Murphree TA, Hansen JR, Smith RD, Kappe SHI, Wright AT, Grundner C.
A Global Survey of ATPase Activity in Plasmodium falciparum Asexual Blood Stages and Gametocytes.
Mol Cell Proteomics. 2018 Jan;17(1):111-120. doi: 10.1074/mcp.RA117.000088. Epub 2017 Oct 27.
Abendroth J, Frando A, Phan IQ, Staker BL, Myler PJ, Edwards TE, Grundner C.
Mycobacterium tuberculosis Rv3651 is a triple sensor-domain protein.
Protein Sci. 2018 Feb;27(2):568-572. doi: 10.1002/pro.3343. Epub 2017 Dec 5.