• Affiliate Associate Professor, Global Health
Christoph Grundner

Center for Infectious Disease Research
307 Westlake Avenue N, Suite 500
Seattle, WA 98109
United States

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Mycobacterium tuberculosis (Mtb) remains the most deadly bacterial pathogen, and rampant drug resistance is requiring renewed efforts to find new and better therapies. The Grundner lab seeks to map the signaling pathways that underlie Mtb’s adaptability and pathogenesis. These studies provide fundamental insight into Mtb biology and identify new targets for therapeutic interference. A major bottleneck in Mtb research on every level is the large number of genes with unknown function in the Mtb genome. We use chemical proteomics approaches towards high-throughput identification of functions for these unknown proteins. These new tools allow probing of even the most divergent enzyme space.

  • PhD (University of Heidelberg (Germany))
  • MS (Humboldt University (Germany))
  • BS (University of Bonn (Germany))
Country Affiliations 
  • German
Health Topics 
  • Infectious Diseases
  • Malaria
  • Pathogenesis
  • TB
Pathobiology research areas 

Ortega C, Frando A, Webb-Robertson BJ, Anderson LN, Fleck N, Flannery EL, Fishbaugher M, Murphree TA, Hansen JR, Smith RD, Kappe SHI, Wright AT, Grundner C.
A Global Survey of ATPase Activity in Plasmodium falciparum Asexual Blood Stages and Gametocytes.
Mol Cell Proteomics. 2018 Jan;17(1):111-120. doi: 10.1074/mcp.RA117.000088. Epub 2017 Oct 27.

Abendroth J, Frando A, Phan IQ, Staker BL, Myler PJ, Edwards TE, Grundner C.
Mycobacterium tuberculosis Rv3651 is a triple sensor-domain protein.
Protein Sci. 2018 Feb;27(2):568-572. doi: 10.1002/pro.3343. Epub 2017 Dec 5.
PMID: 29119630

Systematic Survey of Serine Hydrolase Activity in Mycobacterium tuberculosis Defines Changes Associated with Persistence.
Ortega C, Anderson LN, Frando A, Sadler NC, Brown RW, Smith RD, Wright AT, Grundner C.
Cell Chem Biol. 2016 Feb 18;23(2):290-8.
PMID: 26853625

Agents of change - concepts in Mycobacterium tuberculosis Ser/Thr/Tyr phosphosignalling.
Sherman DR, Grundner C.
Mol Microbiol. 2014 Oct;94(2):231-41.
PMID: 25099260

Mycobacterium tuberculosis supports protein tyrosine phosphorylation.
Kusebauch U, Ortega C, Ollodart A, Rogers RS, Sherman DR, Moritz RL, Grundner C.
Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9265-70.
PMID: 24927537

Mycobacterium tuberculosis Ser/Thr protein kinase B mediates an oxygen-dependent replication switch.
Ortega C, Liao R, Anderson LN, Rustad T, Ollodart AR, Wright AT, Sherman DR, Grundner C.
PLoS Biol. 2014 Jan;12(1)
PMID: 24409094 Free PMC Article

Mycobacterium tuberculosis Rv2179c protein establishes a new exoribonuclease family with broad phylogenetic distribution.
Abendroth J, Ollodart A, Andrews ES, Myler PJ, Staker BL, Edwards TE, Arcus VL, Grundner C.
J Biol Chem. 2014 Jan 24;289(4):2139-47.
PMID: 24311791