- Affiliate Associate Professor, Global Health
Center for Infectious Disease Research
307 Westlake Avenue N, Suite 500
Seattle, WA 98109
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Mycobacterium tuberculosis (Mtb) remains the most deadly bacterial pathogen, and rampant drug resistance is requiring renewed efforts to find new and better therapies. The Grundner lab seeks to map the signaling pathways that underlie Mtb’s adaptability and pathogenesis. These studies provide fundamental insight into Mtb biology and identify new targets for therapeutic interference. A major bottleneck in Mtb research on every level is the large number of genes with unknown function in the Mtb genome. We use chemical proteomics approaches towards high-throughput identification of functions for these unknown proteins. These new tools allow probing of even the most divergent enzyme space.
- PhD (University of Heidelberg (Germany))
- MS (Humboldt University (Germany))
- BS (University of Bonn (Germany))
- Infectious Diseases
Systematic Survey of Serine Hydrolase Activity in Mycobacterium tuberculosis Defines Changes Associated with Persistence.
Ortega C, Anderson LN, Frando A, Sadler NC, Brown RW, Smith RD, Wright AT, Grundner C.
Cell Chem Biol. 2016 Feb 18;23(2):290-8.
Agents of change - concepts in Mycobacterium tuberculosis Ser/Thr/Tyr phosphosignalling.
Sherman DR, Grundner C.
Mol Microbiol. 2014 Oct;94(2):231-41.
Mycobacterium tuberculosis supports protein tyrosine phosphorylation.
Kusebauch U, Ortega C, Ollodart A, Rogers RS, Sherman DR, Moritz RL, Grundner C.
Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9265-70.
Mycobacterium tuberculosis Ser/Thr protein kinase B mediates an oxygen-dependent replication switch.
Ortega C, Liao R, Anderson LN, Rustad T, Ollodart AR, Wright AT, Sherman DR, Grundner C.
PLoS Biol. 2014 Jan;12(1)
PMID: 24409094 Free PMC Article
Mycobacterium tuberculosis Rv2179c protein establishes a new exoribonuclease family with broad phylogenetic distribution.
Abendroth J, Ollodart A, Andrews ES, Myler PJ, Staker BL, Edwards TE, Arcus VL, Grundner C.
J Biol Chem. 2014 Jan 24;289(4):2139-47.